To get 4kkk/month you should:
1) Level negotiation and distribution connections skills till 5
2) Level Iteron V and place two cargo rigs t2 to have 40+km^3 of a volume and be able to pickup all storyline missions including mission where you need to transport giant container. With t1 rigs your volume will be 38433
3) Set home station to Jita IV - Moon 4 - Caldary Navy Assembly Plant or in any other system with maximum gates and which is far from low sec systems.
4) In first run wizard settings->overview presets rename station and gates presets to use the same name
5) Create first run when courier is selected as a function. If you did 2) you should not have drones in the dronehold.
6) Place enough kernite and 1 tritanium (to increase the number of items to be 1+) to home station.
7) During first run after login pause bot and remove Jita from avoidance list. Unpause bot.
Settings:
Dont use any selected corporations. Other settings:
Erase statistics file in mission editor when everything tuned. Bot should not take past experience with new conditions.
I am going to collect my own statistics to compare results. Need to find best value in "Autodetect % of Missions" field yet, but this will take weeks to compare.