I can't seem to make it through the first run. It gets into game, tells me it wasn't able to set the theme (i manually set it, but it doesn't save), then it tells me it can't set the transparency (which is see is an issue). Then it will exit and go through that same process again. Any ideas?

First of all check if you have enabled hardware antialiasing (FXAA mode) in videocard control panel and disable it (globally or for exefile.exe only). It is normally located in 3D settings. Bot works with not modified eve client. Check other settings which may add blur, shadows. Finally check videocard manufacturer website for latest video driver.

If somebody else have this problem, please report. First run may get broken after any eve update.

UPDATE: That fixed it. In the nVidia control panel, I've disabled FXAA and Gamma Control and it completed the First Run. Thanks!