I have gone through and setup exactly as the FAQ's have directed. This however still seems to not be making any sort of ISK. I even have quite a few trading skills at V yet it still isn't going too well. It seems that the bot is making the buy/sell orders but it isn't managing them or something to that effect. Is there any sort of follow along video or advanced configuration that I am missing? I would like to see this work but it simply isn't. I currently have 50 mil in Escrow and have made -20mil. I also have it set with the most profitable items in the system yet it well you get the point. Any pointers?

Start from recording logs and viewing it in logger. Bot is making decisions and showing statuses of each order in the log. If status is OK, you have the best order. If status is not OK, sales or purchases were stopped. You may check what is wrong with particular order. Check my signature for details.

Also it is better to practice manually before trading with bot. Bot is a tool for trader and machine to replace you, but not think for you.

The bot might not be adjusting your orders because the increase or decrease it needs to do is more than the % you set it at. Given you only have 50m in escrow I guess you are dealing in tech1 and Tech2 items, of which, the prices fluctuate dramatically, especially in Jita. Therefore, the price change could be more than the % you have the bot set at. Also, with tech 1 and tech 2, the margins are so small that you are being eaten up by broker fees and tax.